Mark Kramer was a member of the Executive Board of Amsterdam UMC until his retirement in December 2023. He studied medicine in Leiden (cum laude) and was trained as an internist-hematologist in Curaçao and the Leiden University Hospital. From 1994 he worked at the Meander Medical Center in Amersfoort. From 2002 to 2005, he was chairman of the Dutch Internists Association.

In 2007, he was appointed Professor of Internal Medicine at the Vrije Universiteit (VU) in Amsterdam and became head of the Department of Internal Medicine at the VU University Medical Center (VUmc). From 2010, he took on the division chairmanship of the Internal Specialisms. In 2013, HM Queen Beatrix appointed him Officer in the Order of Orange-Nassau. In 2016, he became a member of the Executive Board of VUmc with responsibility for patient care, quality and safety in combination with specialist medical training and strategic and regional collaborations.

He was intensively involved in the merger process between the two University Medical Centers in Amsterdam, the largest healthcare merger in the Netherlands. In July 2018, Amsterdam UMC was born from the Academic Medical Center (AMC), affiliated with the University of Amsterdam, and the VU University Medical Center, affiliated with the Vrije Universiteit Amsterdam.

Since the start of Amsterdam UMC, he has also been chairman of the Regional Body for Acute Care Noord-Holland/Flevoland, and responsible for the coordination of medical care during the COVID crisis in both provinces (3.5 million citizens). As of 2021, he took on the chairmanship of the National Acute Care Network (LNAZ), with the task of coordinating regional acute care and managing the 10 national trauma centers.

In December 2023, he reached retirement age, saying goodbye to the Executive Board of Amsterdam UMC and the chairmanship of the LNAZ. He received the Andreas Medal from the city of Amsterdam for his unifying efforts for the benefit of its citizens during the COVID epidemic.

He is chairman of the Supervisory Board of Forensic Care Specialists and a member of the Supervisory Board of Pluryn (disabled and youth care). As of February 2024, he has been appointed as the first independent chairman of the Dutch Association for Innovative Medicines (VIG).