Jan Gruber, Ph.D., is an Associate Professor at the YLL School of Medicine, Department of Biochemistry, and Yale-NUS. His research focuses on clinical aging clocks, the underlying mechanisms of aging, and the discovery of anti-aging drugs using invertebrate models. In a 2018 study published in Developmental Cell, Dr. Gruber and his team demonstrated that a combination of drugs— including rapamycin, rifampicin, Psora-4, allantoin, and metformin— can significantly extend both lifespan and healthspan, with some combinations nearly doubling these metrics.

Before venturing into aging research, Dr. Gruber studied physics at RWTH Aachen University and earned the Mathematical Tripos (MASt) at Cambridge. He went on to complete an M.Sc. and D.Phil. in Molecular Biophysics and Biochemistry at Oxford, where his work focused on cell cycle control, protein interactions, and rational drug design.

Since 2012, Dr. Gruber has been faculty at NUS and Yale-NUS, where he lectures on free radical biology, aging, complex systems and clinical biomarkers. He has supervised a diverse range of students and is committed to fostering interdisciplinary research in these fields.